Our body cells contain a nucleus, which is like a control center. Inside the nucleus, there are important proteins that regulate cell growth and survival. But sometimes, in cancer cells, these proteins can move out of the nucleus when they shouldn't, causing the cancer cells to grow uncontrollably.

Selinexor steps in to stop this from happening. It blocks a protein called XPO1, which acts like a taxi, carrying these important proteins out of the nucleus. By blocking XPO1, Selinexor keeps these proteins trapped inside the nucleus, where they're needed to regulate cell growth.

So, in simple terms, Selinexor helps keep the bad cancer cells in check by making sure the proteins that control their growth stay where they should be, inside the nucleus. This can slow down or even stop the growth of cancer cells, helping to treat the cancer.

Have any queries, book a consultation with our Oncology Clinical Specialist

Selinexor is useful for treating certain types of cancer, specifically:

1. **Multiple Myeloma**: This is a type of cancer that affects plasma cells in the bone marrow, causing bone pain, weakness, and problems with the kidneys and immune system. Selinexor may be used when other treatments have not worked well enough.

2. **Diffuse Large B-Cell Lymphoma (DLBCL)**: DLBCL is a type of non-Hodgkin lymphoma, a cancer that affects the lymphatic system. It can cause symptoms like swollen lymph nodes, fever, and weight loss. Selinexor may be used in people with DLBCL who have not responded to other treatments or whose cancer has come back after treatment.

In simple terms, Selinexor is a treatment option for people with certain types of cancer, especially when other treatments have not been effective. It works by slowing down or stopping the growth of cancer cells, helping to manage the disease and improve outcomes for patients.

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If you miss a dose of Selinexor, it's important to take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, just skip the missed dose and take your next dose at the regular time. 

It's essential to avoid taking extra doses to make up for the missed one. Taking too much Selinexor can increase the risk of side effects. If you're unsure about what to do, it's best to check with your doctor or pharmacist for guidance. They can provide you with personalized advice based on your specific situation.

Please book a consultation with our Oncology Clinical Specialist to know more about what happens if you miss the dose.

Selinexor can cause side effects. Some common side effects may include:

1. **Nausea and vomiting**: Feeling sick to your stomach and throwing up.
2. **Fatigue**: Feeling very tired or weak.
3. **Decreased appetite**: Not feeling hungry or wanting to eat less.
4. **Diarrhea**: Having loose or watery bowel movements.
5. **Low blood cell counts**: This can lead to anemia (low red blood cells), which can cause fatigue and weakness, or neutropenia (low white blood cells), which can increase the risk of infections.

These side effects can vary in severity from person to person. It's important to tell your doctor about any side effects you experience while taking Selinexor. They can provide guidance on managing them and may adjust your treatment if needed. Additionally, there can be more serious side effects, so it's crucial to report any new or worsening symptoms to your doctor promptly.

Have any queries, book a consultation with our Oncology Clinical Specialist

If you're taking other medicines along with Selinexor, it's important to let our doctor know. Some medicines might interact with Selinexor, which means they can affect how well it works or cause more side effects.

Our doctor can check if any of the medicines you're taking might interact with Selinexor and make sure it's safe for you to take them together. It's always best to talk to our doctor before starting or stopping any medicines, including prescription drugs, over-the-counter medicines, and supplements. That way, you can make sure you're getting the most benefit from your treatment while staying safe.

Have any queries, book a consultation with our Oncology Clinical Specialist

Here's some safety advice regarding pregnancy, liver, or kidney issues when using Selinexor:

1. **Pregnancy**: If you're pregnant, planning to become pregnant, or breastfeeding, it's important to discuss this with our doctor before starting Selinexor. This medicine may harm an unborn baby, so your doctor can help you weigh the benefits and risks and decide on the best course of action.

2. **Liver or Kidney Problems**: If you have liver or kidney issues, it's crucial to let our doctor know before taking Selinexor. Your liver and kidneys help process medicines, so if they're not working properly, Selinexor may build up in your body and cause more side effects. Your doctor can monitor your condition and adjust your Selinexor dosage if needed to keep you safe.

By communicating openly with your doctor and following their advice, you can ensure the safe and effective use of Selinexor for your specific situation.

Have any queries, book a consultation with our Oncology Clinical Specialist