🧠 TL;DR Daratumumab is a CD38-targeted immunotherapy used in multiple myeloma and amyloidosis Not every patient needs it immediately-timing is critical Infusion reactions can occur in up to 50% patients initially, but are manageable It interferes with blood tests (Coombs test & protein electrophoresis) Dose does NOT need adjustment in kidney failure or dialysis Cost is typically ₹2–3 lakh/month, but varies due to support programs Many patients consult me to decide whether th